- A long-term survival case of advanced hepatocellular carcinoma with portal vein thrombosis successfully treated with multimodal treatments
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Ju Hyun Choi, Han Eul Song, Chang Il Kwon, Kwang Hyun Ko, Sung Pyo Hong, Seong Gyu Hwang, Pil Won Park, Kyu Sung Rim, Man Deuk Kim, Sung Won Kwon
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):66-70. Published online June 30, 2007
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Abstract
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- We reported a 52-year-old women with hepatocellular carcinoma (HCC) of 10 cm in diameter involving entire
right lobe with advanced tumor thrombosis in the both branches and main trunk of portal vein. She was treated
with multimodal treatments resulting in a long-term survival of more than 5 years. At first, she was treated with
hepatic arterial chemotherapy (HAC) using cisplatin and 5-FU for 5 cycles and radiation therapy in September
2002. The tumor size decreased and the main and left portal vein thrombosis was disappeared. Although, she had
been treated with the 3th radiofrequency ablation (RFA) and the 3th transarterial chemoembolization (TACE) three
times for the treatment of main tumor, follow-up CT scan still showed marginal viable tumor at the segment 5.
Therefore, she was underwent right lobectomy of the liver and splenectomy. Further TACE was performed once
for the small remnant tumor around inferior vena cava at the postoperative 4 months. Finally, she has been
survived for over 5 years from the initial treatment and 23 months after operation without evidence of recurrence.
We suggest that the long-term survival was achieved in this patient through appropriate treatment selections at
the right time, such as HAC, RFA, TACE, hepatic resection and external radiotherapy based on changes in
diagnostic imaging and tumor markers.
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